Our Research

Virtually every cell in the body has the same genetic information yet individual cells can achieve highly specialized states with vastly differing morphology and functionality. During development this is achieved through a series of cell expansion and differentiation cascades that allows initially pluripotent cells to commit to altered cells fates in a remarkably stable manner. Given that these outcomes are achieved with a fixed genetic complement (i.e. the same DNA in every cell), it reasons specific cell types must invoke with high fidelity mechanisms that specify and restrict their capacity to express the correct complement of genes.

Learn more by watching Rob's Francis Crick Prize Lecture at the Royal Society.

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