KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity
Turberfield AH, Kondo T, Nakayama M, Koseki Y, King HW, Koseki H, Klose RJ.( 2019) KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.
Nucleic Acids Res. 2019 Sep 26;47(17):9005-9023. doi: 10.1093/nar/gkz607.
PMID:31363749
Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression
Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, King HW, Koseki H, Klose RJ. (2019) Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression.
Mol Cell. 2019 Jun 6;74(5):1020-1036.e8. doi: 10.1016/j.molcel.2019.03.024.
PMID:31029541
Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.
King H.W., Fursova N.A., Blackledge N.P., Klose R.J. (2018) Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes. Genome Res. 28(10):1494-1507.
Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1
Kulkarni A, Taylor GP, Klose RJ, Schofield CJ, Bangham CR. Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1. JCI Insight. 2018 Oct 18;3(20):e123196. doi: 10.1172/jci.insight.123196. PMID: 30333309; PMCID: PMC6237452.
PMID: 30333309
PMCID: PMC6237452
Publication – Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.
Congratulations to Hamish, Nadya and Neil for their latest publication in Genome Research!
FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment
Dimitrova E., Kondo T., Feldmann A., Nakayama M., Koseki Y., Konietzny R., Kessler B.M., Koseki H., Klose R.J. (2018) FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment. elife. 7,e37084
Publication – FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment
Congratulations to Emilia and Angelika for their latest publication in eLife!
Check it out here:
Lab meeting doughnuts!
Biochemical Identification of Nonmethylated DNA by BioCAP-Seq
Long H.K., Rose N.R., Blackledge N.P., Klose R.J. (2018) Biochemical Identification of Nonmethylated DNA by BioCAP-Seq. Methods Mol Biol. 1766:15-29
Welcome to our new PhD student Deniz!
Welcome!
Rob is awarded an Investigator Award by the Wellcome Trust
Congratulations to Rob for his Wellcome Investigator Award! New Postdoc positions will be advertised soon.
Christmas Dinner 2017
Klose Lab retreat – Isle of Wight
Welcome to our new Part II students Alex and Hiro!
Welcome!
The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin
Brown D.A., Di Cerbo V., Feldmann A., Ahn J., Ito S., Blackledge N.P., Nakayama M., McClellan M., Dimitrova E., Turberfield A.H., Long H.K., King H.W., Kriaucionis S., Schermelleh L., Kutateladze T.G., Koseki H., Klose R.J. (2017) The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin. Cell Rep. 20(10):2313-2327
https://www.ncbi.nlm.nih.gov/pubmed/28877467
http://www.sciencedirect.com/science/article/pii/S2211124717311373?via%3Dihub
Publication – The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin
Congratulations to Dave, Vincenzo and all of the co-authors for their latest publication in Cell Reports!
https://www.ncbi.nlm.nih.gov/pubmed/28877467
https://www.cell.com/cell-reports/fulltext/S2211-1247(17)31137-3
Klose Lab BBQ
Punting with the Brockdorff Lab
Easter Egg Hunt
Rob is awarded Chair of Genetics at Keble
Congratulations to Rob, who has just been appointed as Chair of Genetics in the Department of Biochemistry. He will be a fellow of Keble College.
Dr Paula Dobrinic joins the lab!
Welcome to Paula, who is joining us from Vlatka Zoldos’s lab at the University of Zagreb, Croatia. She will be investigating how CpG islands contribute to gene regulation.
PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes
Endoh, M., Endo, T.A., Shinga, J., Hayashi, K., Farcas, A., Ma, K.W., Ito, S., Sharif, J., Endoh, T., Onaga, N., Nakayama, M., Ishikura, T., Masui, O., Kessler, B.M., Suda, T., Ohara, O., Okuda, A., Klose, R., Koseki, H. (2017) PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes. elife. 6,e21064
The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells
King, H.W., Klose, R.J. (2017) The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells. elife. 6,e22631
Publication – The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells
Congratulations to Hamish for the acceptance of his paper in eLIFE!
Check it out here:
MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia
Kerry, J., Godfrey, L., Repapi, E., Tapia, M., Blackledge, N.P., Ma, H., Ballabio, E., O’Byrne, S., Ponthan, F., Heidenreich, O., Roy, A., Roberts, I., Konopleva, M., Klose, R.J., Geng, H., Milne, T.A. (2017) MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia. Cell Rep. 18(2),482-495
https://www.ncbi.nlm.nih.gov/pubmed/28076791
http://www.sciencedirect.com/science/article/pii/S2211124716317612