Rob Klose
SET1/MLL complexes control transcription independently of H3K4me3
Au HYA, Szczurek AT, de Krijger I, Kjelstrup-Osorio N, Hughes AL, Lastuvkova A, Vermeulen M, Klose RJ.
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions
Li H, Dalgleish JLT, Lister G, Maristany MJ, Huertas J, Dopico-Fernandez AM, Hamley JC, Denny N, Bloye G, Zhang W, Hentges L, Doll R, Wei Y, Maresca M, Dimitrova E, Pytowski L, Tunnacliffe EAJ, Kassouf M, Higgs D, de Wit E, Klose RJ, Schermelleh L, Collepardo-Guevara R, Milne TA, Davies JOJ.
Cell, 2025.
Chromatin profiling identifies putative dual roles for H3K27me3 in regulating cell type-specific genes and transposable elements in choanoflagellates
Gahan JM, Helfrich LW, Wetzel LA, Bhanu NV, Yuan ZF, Garcia BA, Klose RJ, de Mendoza A, Booth DS.
Nature Communications, 2025.
MGA directly recruits SETDB1/ATF7IP for histone H3K9me3 mark on meiosis-related genes in mouse embryonic stem cells
Uranishi K, Hirasaki M, Nishimoto M, Klose RJ, Okuda A, Suzuki A.
iScience, 2025.
The PNUTS phosphatase complex controls transcription pause release
Kelley JR, Dimitrova E, Maciuszek M, Nguyen HT, Szczurek AT, Hughes AL, Blackledge NP, Kettenbach AN, Klose RJ.
Molecular Cell, 2024.
Epi-microRNA mediated metabolic reprogramming counteracts hypoxia to preserve affinity maturation
Nakagawa R, Llorian M, Varsani-Brown S, Chakravarty P, Camarillo JM, Barry D, George R, Blackledge NP, Duddy G, Kelleher NL, Klose RJ, Turner M, Calado DP.
Nature Communications, 2024.
Paper celebration
Great to celebrate a recent paper acceptance with the team and collagues on the floor!


The Polycomb system sustains promoters in a deep OFF state by limiting pre-initiation complex formation to counteract transcription
Szczurek AT, Dimitrova E, Kelley JR, Blackledge NP, Klose RJ.
Nature Cell Biology 2024
Extensive DNA methylome rearrangement during early lamprey embryogenesis.
Angeloni A, Fissette S, Kaya D, Hammond JM, Gamaarachchi H, Deveson IW, Klose RJ, Li W, Zhang X, Bogdanovic O.
Nat Communication 2024.
Fun making competent bugs!
Competent bug making party!
Congratulations to Dr Au!
