The Klose lab is interested in understanding how chromatin based and epigenetic processes contribute to regulation of gene expression.
To achieve this we use cutting edge biochemical, molecular, genetic, and genomic approaches in model stem cell and developmental systems.
Ultimately, our motivation is to understand how chromatin impinges on gene expression in normal cell biology as a way of informing therapeutic approaches to counteract its perturbation in cancer and other human diseases.
"I study Polycomb-mediated gene repression through employing microscopy-based single-cell/single-molecule techniques"
"We are interested in how chromatin modification and architecture contribute to gene regulation."
"I support our research by generating transgenic mES cell lines "
"I am interested in how the H3K4 histone methyltransferases regulate transcription"
"Through systematic dissection of PRC1 complexes, I aim to identify the molecular determinants of gene repression by the Polycomb system."
"My aim is to kinetically dissect the Polycomb-mediated regulation of gene expression by using rapid degron-based approaches and time-resolved genomic analysis"
"I study how promoter-binding proteins affect genome structure."
"I am interested in how CpG islands contribute to gene regulation."
"I am using biochemical and structural approaches to investigate the molecular mechanisms of gene regulation by Trithorax group proteins"
"I am interested in how Polycomb repressive complexes get to their target sites in the genome and how they counteract the process of transcription"
"I'm applying single particle tracking to study PRC1 dynamics"
"I am investigating the role of KDM2 proteins in regulating chromatin architecture and transcription"
"I'm interested in the biochemical isolation and functional dissection of the CpG island proteome"