Klose Lab @ University of Oxford

The Klose lab is interested in understanding how chromatin based and epigenetic processes contribute to regulation of gene expression.

To achieve this we use cutting edge biochemical, molecular, genetic, and genomic approaches in model stem cell and developmental systems.

Ultimately, our motivation is to understand how chromatin impinges on gene expression in normal cell biology as a way of informing therapeutic approaches to counteract its perturbation in cancer and other human diseases.