Klose Lab @ University of Oxford
The Klose lab is interested in understanding how chromatin based and epigenetic processes contribute to regulation of gene expression.
To achieve this we use cutting edge biochemical, molecular, genetic, and genomic approaches in model stem cell and developmental systems.
Ultimately, our motivation is to understand how chromatin impinges on gene expression in normal cell biology as a way of informing therapeutic approaches to counteract its perturbation in cancer and other human diseases.
Aleksander Szczurek
Aleksander Szczurek 
"I study Polycomb-mediated gene repression through employing microscopy-based single-cell/single-molecule techniques"
Rob Klose 
"We are interested in how chromatin modification and architecture contribute to gene regulation."
Anna Lastuvkova 
"I support our research by generating transgenic mES cell lines "
Amy Hughes 
"I am interested in how the H3K4 histone methyltransferases regulate transcription"
Nadezda Fursova 
"Through systematic dissection of PRC1 complexes, I aim to identify the molecular determinants of gene repression by the Polycomb system."
Paula Dobrinic 
"My aim is to kinetically dissect the Polycomb-mediated regulation of gene expression by using rapid degron-based approaches and time-resolved genomic analysis"
Angelika Feldmann 
"I study how promoter-binding proteins affect genome structure."
Emma Smith
"I am interested in how CpG islands contribute to gene regulation."
Jess Kelley
"I am using biochemical and structural approaches to investigate the molecular mechanisms of gene regulation by Trithorax group proteins"
Neil Blackledge
"I am interested in how Polycomb repressive complexes get to their target sites in the genome and how they counteract the process of transcription"
Miles Huseyin
"I'm applying single particle tracking to study PRC1 dynamics"
Anne Turberfield
"I am investigating the role of KDM2 proteins in regulating chromatin architecture and transcription"
Deniz Kaya 
"I'm interested in the biochemical isolation and functional dissection of the CpG island proteome"
