Publications

Blackledge, N.P., Rose, N.R., Klose, R.J. (2015) Targeting Polycomb systems to regulate gene expression: modifications to a complex story. Nat Rev Mol Cell Biol. 16 (11), 643-9

http://www.ncbi.nlm.nih.gov/pubmed/26420232

http://www.nature.com/nrm/journal/v16/n11/full/nrm4067.html

Blackledge, N.P., Farcas, A.M., Kondo, T., King, H.W., McGouran, J.F., Hanssen, L.L., Ito, S., Cooper, S., Kondo, K., Koseki, Y., Ishikura, T., Long, H.K., Sheahan, T.W., Brockdorff, N., Kessler, B.M., Koseki, H., Klose, R.J. (2014) Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation. Cell. 157 (6), 1445-1459

http://www.sciencedirect.com/science/article/pii/S0092867414005893

http://www.ncbi.nlm.nih.gov/pubmed/24856970

Rose, N. R. and Klose R. J. Understanding the relationship between DNA methylation and histone lysine methylation. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms. 1839 (12), 1362-1372

http://www.sciencedirect.com/science/article/pii/S1874939914000285

http://www.ncbi.nlm.nih.gov/pubmed/24560929

Long, H. K., Blackledge, N. P. and Klose, R. J. (2013) ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Biochem Soc Trans. 41, 727-740

http://www.biochemsoctrans.org/bst/041/0727/bst0410727.htm

http://www.ncbi.nlm.nih.gov/pubmed/23697932

Long, H. K., Sims, D., Heger, A., Blackledge, N. P., Kutter, C., Wright, M. L., Grützner, F., Odom, D. T., Patient, R., Ponting, C. P. and Klose, R. J. (2013) Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. elife. 2, e00348

http://elife.elifesciences.org/content/2/e00348

http://www.ncbi.nlm.nih.gov/pubmed/23467541

http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE43512

Rose, N. R., Woon, E. C., Tumber, A., Walport, L. J., Chowdhury, R., Li, X. S., King, O. N., Lejeune, C., Ng, S. S., Krojer, T., Chan, M. C., Rydzik, A. M., Hopkinson, R. J., Che, K. H., Daniel, M., Strain-Damerell, C., Gileadi, C., Kochan, G., Leung, I. K., Dunford, J., Yeoh, K. K., Ratcliffe, P. J., Burgess-Brown, N., von Delft, F., Muller, S., Marsden, B., Brennan, P. E., McDonough, M. A., Oppermann, U., Klose, R. J., Schofield, C. J. and Kawamura, A. (2012) Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 55, 6639-6643

http://pubs.acs.org/doi/abs/10.1021/jm300677j

Blackledge, N. P., Long, H. K., Zhou, J. C., Kriaucionis, S., Patient, R. and Klose, R. J. (2012) Bio-CAP: a versatile and highly sensitive technique to purify and characterise regions of non-methylated DNA. Nucleic Acids Res. 40, e32

http://nar.oxfordjournals.org/content/40/4/e32.long

Chowdhury, R., Yeoh, K. K., Tian, Y. M., Hillringhaus, L., Bagg, E. A., Rose, N. R., Leung, I. K., Li, X. S., Woon, E. C., Yang, M., McDonough, M. A., King, O. N., Clifton, I. J., Klose, R. J., Claridge, T. D., Ratcliffe, P. J., Schofield, C. J. and Kawamura, A. (2011) The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep. 12, 463-469

https://www.ndm.ox.ac.uk/publications/384687

Landeira, D., Sauer, S., Poot, R., Dvorkina, M., Mazzarella, L., Jorgensen, H. F., Pereira, C. F., Leleu, M., Piccolo, F. M., Spivakov, M., Brookes, E., Pombo, A., Fisher, C., Skarnes, W. C., Snoek, T., Bezstarosti, K., Demmers, J., Klose, R. J., Casanova, M., Tavares, L., Brockdorff, N., Merkenschlager, M. and Fisher, A. G. (2010) Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol. 12, 618-624

http://www.nature.com/ncb/journal/v12/n6/full/ncb2065.html

Blackledge, N. P., Zhou, J. C., Tolstorukov, M. Y., Farcas, A. M., Park, P. J. and Klose, R. J. (2010) CpG islands recruit a histone H3 lysine 36 demethylase. Mol Cell. 38, 179-190

http://www.sciencedirect.com/science/article/pii/S1097276510002868

http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE21202

Blackledge, N. P. and Klose, R. J. (2010) Histone lysine methylation: an epigenetic modification? Epigenomics. 2, 151-161

Loenarz, C., Ge, W., Coleman, M. L., Rose, N. R., Cooper, C. D., Klose, R. J., Ratcliffe, P. J. and Schofield, C. J. (2010) PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Hum Mol Genet. 19, 217-222

http://hmg.oxfordjournals.org/content/19/2/217.long

Ho, K. L., McNae, I. W., Schmiedeberg, L., Klose, R. J., Bird, A. P. and Walkinshaw, M. D. (2008) MeCP2 binding to DNA depends upon hydration at methyl-CpG. Mol Cell. 29, 525-531

http://www.sciencedirect.com/science/article/pii/S1097276508000968

Klose, R. J., Gardner, K. E., Liang, G., Erdjument-Bromage, H., Tempst, P. and Zhang, Y. (2007) Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol. 27, 3951-3961

http://mcb.asm.org/content/27/11/3951.long

Yamane, K., Tateishi, K., Klose, R. J., Fang, J., Fabrizio, L. A., Erdjument-Bromage, H., Taylor-Papadimitriou, J., Tempst, P. and Zhang, Y. (2007) PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell. 25, 801-812

http://www.sciencedirect.com/science/article/pii/S1097276507001463

Lee, N., Zhang, J., Klose, R. J., Erdjument-Bromage, H., Tempst, P., Jones, R. S. and Zhang, Y. (2007) The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase. Nat Struct Mol Biol. 14, 341-343

http://www.nature.com/nsmb/journal/v14/n4/full/nsmb1216.html

Klose, R. J., Yan, Q., Tothova, Z., Yamane, K., Erdjument-Bromage, H., Tempst, P., Gilliland, D. G., Zhang, Y. and Kaelin, W. G., Jr. (2007) The retinoblastoma binding protein RBP2 is an H3K4 demethylase. Cell. 128, 889-900

http://www.sciencedirect.com/science/article/pii/S0092867407001948