CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions
Feldmann A, Dimitrova E, Kenney A, Lastuvkova A, Klose RJ. CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions. Nucleic Acids Res. 2020 Apr 6;48(6):2942-2955. doi: 10.1093/nar/gkaa064. PMID: 31996894; PMCID: PMC7102981.
PMID: 31996894
PMCID: PMC7102981
DOI: 10.1093/nar/gkaa064
Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation
Hughes AL, Kelley JR, Klose RJ. Understanding the interplay between CpG island-associated gene promoters and H3K4 methylation. Biochim Biophys Acta Gene Regul Mech. 2020 Aug;1863(8):194567. Epub 2020 Apr 29. PMID: 32360393; PMCID: PMC7294231.
doi: 10.1016/j.bbagrm.2020.194567.
ATACing DNA Methylation during Differentiation
Kriaucionis S, Klose RJ. ATACing DNA Methylation during Differentiation. Mol Cell. 2020 Mar 19;77(6):1159-1161. doi: 10.1016/j.molcel.2020.02.026. PMID: 32200796.
PMID: 32200796
PRC1 Catalytic Activity Is Central to Polycomb System Function
Blackledge NP, Fursova NA, Kelley JR, Huseyin MK, Feldmann A, Klose RJ. PRC1 Catalytic Activity Is Central to Polycomb System Function. Mol Cell. 2020 Feb 20;77(4):857-874.e9. doi: 10.1016/j.molcel.2019.12.001. Epub 2019 Dec 27. PMID: 31883950; PMCID: PMC7033600.
PMID: 31883950
PMCID: PMC7033600
Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells
Rhodes JDP, Feldmann A, Hernández-Rodríguez B, Díaz N, Brown JM, Fursova NA, Blackledge NP, Prathapan P, Dobrinic P, Huseyin MK, Szczurek A, Kruse K, Nasmyth KA, Buckle VJ, Vaquerizas JM, Klose RJ. Cohesin Disrupts Polycomb-Dependent Chromosome Interactions in Embryonic Stem Cells. Cell Rep. 2020 Jan 21;30(3):820-835.e10. doi: 10.1016/j.celrep.2019.12.057. PMID: 31968256; PMCID: PMC6988126.
PMID: 31968256
PMCID: PMC6988126
KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity
Turberfield AH, Kondo T, Nakayama M, Koseki Y, King HW, Koseki H, Klose RJ.( 2019) KDM2 proteins constrain transcription from CpG island gene promoters independently of their histone demethylase activity.
Nucleic Acids Res. 2019 Sep 26;47(17):9005-9023. doi: 10.1093/nar/gkz607.
PMID:31363749
Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression
Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, King HW, Koseki H, Klose RJ. (2019) Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression.
Mol Cell. 2019 Jun 6;74(5):1020-1036.e8. doi: 10.1016/j.molcel.2019.03.024.
PMID:31029541
Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.
King H.W., Fursova N.A., Blackledge N.P., Klose R.J. (2018) Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes. Genome Res. 28(10):1494-1507.
Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1
Kulkarni A, Taylor GP, Klose RJ, Schofield CJ, Bangham CR. Histone H2A monoubiquitylation and p38-MAPKs regulate immediate-early gene-like reactivation of latent retrovirus HTLV-1. JCI Insight. 2018 Oct 18;3(20):e123196. doi: 10.1172/jci.insight.123196. PMID: 30333309; PMCID: PMC6237452.
PMID: 30333309
PMCID: PMC6237452
Publication – Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.
Congratulations to Hamish, Nadya and Neil for their latest publication in Genome Research!
FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment
Dimitrova E., Kondo T., Feldmann A., Nakayama M., Koseki Y., Konietzny R., Kessler B.M., Koseki H., Klose R.J. (2018) FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment. elife. 7,e37084
Publication – FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment
Congratulations to Emilia and Angelika for their latest publication in eLife!
Check it out here:
Lab meeting doughnuts!
Biochemical Identification of Nonmethylated DNA by BioCAP-Seq
Long H.K., Rose N.R., Blackledge N.P., Klose R.J. (2018) Biochemical Identification of Nonmethylated DNA by BioCAP-Seq. Methods Mol Biol. 1766:15-29
Welcome to our new PhD student Deniz!
Welcome!
Rob is awarded an Investigator Award by the Wellcome Trust
Congratulations to Rob for his Wellcome Investigator Award! New Postdoc positions will be advertised soon.
Christmas Dinner 2017
Klose Lab retreat – Isle of Wight
Welcome to our new Part II students Alex and Hiro!
Welcome!
The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin
Brown D.A., Di Cerbo V., Feldmann A., Ahn J., Ito S., Blackledge N.P., Nakayama M., McClellan M., Dimitrova E., Turberfield A.H., Long H.K., King H.W., Kriaucionis S., Schermelleh L., Kutateladze T.G., Koseki H., Klose R.J. (2017) The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin. Cell Rep. 20(10):2313-2327
https://www.ncbi.nlm.nih.gov/pubmed/28877467
http://www.sciencedirect.com/science/article/pii/S2211124717311373?via%3Dihub
Publication – The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin
Congratulations to Dave, Vincenzo and all of the co-authors for their latest publication in Cell Reports!
https://www.ncbi.nlm.nih.gov/pubmed/28877467
https://www.cell.com/cell-reports/fulltext/S2211-1247(17)31137-3
Klose Lab BBQ
Punting with the Brockdorff Lab
Easter Egg Hunt
Rob is awarded Chair of Genetics at Keble
Congratulations to Rob, who has just been appointed as Chair of Genetics in the Department of Biochemistry. He will be a fellow of Keble College.