klosedev
Klose Lab Retreat 2015 – Niederau, Austria
The Klose lab has returned safely from another highly successful lab retreat. Based in the small Austrian village Niederau, the retreat proved to be stimulating scientifically and socially within the lab. When the lab wasn’t discussing science, we made the most of the fantastic weather and spent time enjoying the fantastic mountain scenery (and the ski slopes!).
Dave passed his DPhil viva!
Congratulations to Dave for passing his DPhil viva!
Well done Dr Brown!
Dr Angelika Feldmann joined the lab!
Angelika is joining us from Dirk Schubeler’s lab at the FMI, Basel. She will be focusing on the mechanisms by which different promoter classes coordinate their regulatory inputs in vertebrates.
Conferences – EMBO Transcription and Chromatin, and CSHL Epigenetics and Chromatin
Lab members attended two conferences recently.
Hamish attended the EMBO Transcription and Chromatin conference in Heidelberg, Germany, where he presented a poster.
Rob and Neil also attended the Cold Spring Harbor Laboratory Epigenetics and Chromatin conference in the US, where Rob presented the latest work from the lab on polycomb recruitment.
Rob is scientist of the month at abcam for July 2014
Read about it here:
http://www.abcam.com/epigenetics/scientist-of-the-month-rob-klose
Celebrating Cell paper success with the Brockdorff Lab
Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment
Cooper, S., Dienstbier, M., Hassan, R., Schermelleh, L., Sharif, J., Blackledge, N.P., De Marco, V., Elderkin, S., Koseki, H., Klose, R., Heger, A., Brockdorff, N. Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment. Cell Reports. 7 (5), 1456-1470
http://www.sciencedirect.com/science/article/pii/S221112471400299X
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation
Blackledge, N.P., Farcas, A.M., Kondo, T., King, H.W., McGouran, J.F., Hanssen, L.L., Ito, S., Cooper, S., Kondo, K., Koseki, Y., Ishikura, T., Long, H.K., Sheahan, T.W., Brockdorff, N., Kessler, B.M., Koseki, H., Klose, R.J. (2014) Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation. Cell. 157 (6), 1445-1459
http://www.sciencedirect.com/science/article/pii/S0092867414005893
Rob is awarded Monsanto Senior Research Fellowship at Exeter
Congratulations to Rob, who has just been awarded the Monsanto Senior Research Fellowship at Exeter College here in Oxford.
Nathan presented his work at the EMBO/FEBS Lecture Course ‘Nuclear Proteomics’ in Kos, Greece
Anca passed her DPhil viva!
Congratulations to Anca for passing her DPhil viva! Well done Dr Farcas!
Dr Vincenzo di Cerbo joined the lab!
Vincenzo is joining us from Rob Schneider’s lab at the IGBMC, Strasbourg. He will be studying how Trithorax protein complexes regulate transcription in mouse embryonic stem cells.
Understanding the relationship between DNA methylation and histone lysine methylation
Rose, N. R. and Klose R. J. Understanding the relationship between DNA methylation and histone lysine methylation. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms. 1839 (12), 1362-1372
http://www.sciencedirect.com/science/article/pii/S1874939914000285
Publication – Understanding the relationship between DNA methylation and histone lysine methylation
Nathan’s review article on the connection between DNA methylation and histone lysine methylation has now been accepted for publication. Read the final article here:
http://www.sciencedirect.com/science/article/pii/S1874939914000285
Dr Emilia Dimitrova joined the lab!
Welcome to Dr Emilia Dimitrova who has joined our lab. Emilia completed her PhD at the Babraham Institute with Sarah Elderkin, and she joins our lab to work on the zinc-finger CxxC domain proteins.
Hannah passed her DPhil viva!
We celebrated with Hannah after she successfully defended her thesis!
Hannah’s viva – well done Hannah!
Chromatin sampling–an emerging perspective on targeting polycomb repressor proteins
Klose, R. J., Cooper, S., Farcas, A. M., Blackledge, N. P., and Brockdorff, N. (2013) Chromatin sampling–an emerging perspective on targeting polycomb repressor proteins. PLoS Genet. 9, e1003717
http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1003717
ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection
Long, H. K., Blackledge, N. P. and Klose, R. J. (2013) ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection. Biochem Soc Trans. 41, 727-740
Publication – ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection
Congratulations to Hannah and Neil for their latest review article.
Read the article here:
Dinner at Exeter College May 2013
Baby James visits the lab – congratulations Neil and Sarah!
Publication – Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates
Congratulations to Hannah for her publication in eLife today. Check out the paper here:
Celebrating Anca and Hannah’s eLife paper
Today we celebrated Anca and Hannah’s eLife papers with a glass or two of champagne. Well done Anca and Hannah!
Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates
Long, H. K., Sims, D., Heger, A., Blackledge, N. P., Kutter, C., Wright, M. L., Grützner, F., Odom, D. T., Patient, R., Ponting, C. P. and Klose, R. J. (2013) Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates. elife. 2, e00348
http://elife.elifesciences.org/content/2/e00348