Dr Paula Dobrinic joins the lab!
Welcome to Paula, who is joining us from Vlatka Zoldos’s lab at the University of Zagreb, Croatia. She will be investigating how CpG islands contribute to gene regulation.
PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes
Endoh, M., Endo, T.A., Shinga, J., Hayashi, K., Farcas, A., Ma, K.W., Ito, S., Sharif, J., Endoh, T., Onaga, N., Nakayama, M., Ishikura, T., Masui, O., Kessler, B.M., Suda, T., Ohara, O., Okuda, A., Klose, R., Koseki, H. (2017) PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes. elife. 6,e21064
The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells
King, H.W., Klose, R.J. (2017) The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells. elife. 6,e22631
Publication – The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells
Congratulations to Hamish for the acceptance of his paper in eLIFE!
Check it out here:
MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia
Kerry, J., Godfrey, L., Repapi, E., Tapia, M., Blackledge, N.P., Ma, H., Ballabio, E., O’Byrne, S., Ponthan, F., Heidenreich, O., Roy, A., Roberts, I., Konopleva, M., Klose, R.J., Geng, H., Milne, T.A. (2017) MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia. Cell Rep. 18(2),482-495
https://www.ncbi.nlm.nih.gov/pubmed/28076791
http://www.sciencedirect.com/science/article/pii/S2211124716317612
Christmas Dinner
Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis
Ernst, C., Pike, J., Aitken, S.J., Long, H.K., Eling, N., Stojic, L., Ward, M.C., Connor, F., Rayner, T.F., Lukk, M., Klose, R.J., Kutter, C., Odom, D.T. (2016) Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis. elife. 5,e20235
RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
Rose, N.R., King, H.W., Blackledge, N.P., Fursova, N.A., Ember, K.J., Fischer, R., Kessler, B.M., Klose, R.J. (2016) RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes. elife. 5,e18591
Publication – RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
Congratulations to Nathan, Hamish and all of the co-authors for their latest publication in eLIFE!
Read the full article here:
Anne wins prize for DPhil talk
Congratulations to Anne for being awarded a prize for her presentation at the Department of Biochemistry DPhil Symposium.
Welcome to our new Part II students Praveen and Jess!
Welcome!
Dr Mariya Georgieva joined the lab!
Welcome!
Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved
Long, H.K., King, H.W., Patient, R.K., Odom, D.T., Klose, R.J. (2016) Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved. Nucleic Acids Res. 44(14), 6693-6706
Rob gives Royal Society Francis Crick lecture
Histone demethylases in chromatin biology and beyond
Dimitrova, E., Turberfield, A.H., Klose, R.J. (2015) Histone demethylases in chromatin biology and beyond. EMBO Rep. 16 (12), 1620-39
Publication – REVIEW Histone demethylases in chromatin biology and beyond
Emilia and Anne’s review article discussing the varied roles of histone demethylases is now online!
Check out the full review here:
Rob gives 2015 Francis Crick Lecture at the Royal Society
This evening Rob gave the 2015 Francis Crick Lecture at the Royal Society in London. Congratulations to Rob for a fantastic talk!
Dave’s Post-Viva Celebrations
Farewell for Laura
Hamish wins prize for DPhil talk
Congratulations to Hamish for being awarded a prize for his presentation at the Department of Biochemistry DPhil Symposium.
Targeting Polycomb systems to regulate gene expression: modifications to a complex story
Blackledge, N.P., Rose, N.R., Klose, R.J. (2015) Targeting Polycomb systems to regulate gene expression: modifications to a complex story. Nat Rev Mol Cell Biol. 16 (11), 643-9
Publication – REVIEW Targeting Polycomb systems to regulate gene expression
Neil and Nathan’s review article on polycomb targeting is now available online! Well done to Neil and Nathan for their hard work.
Check out the full review here:
http://www.nature.com/nrm/journal/vaop/ncurrent/abs/nrm4067.html
Pub trip to welcome Nadya and Rebecca to the lab
Wine Tasting – July 2015
Conference – 40th FEBS Congress
Vincenzo recently won a travel grant to attend the 15th FEBS Young Scientists’ Forum, joined with the 40th FEBS Congress in Berlin, where he was given the opportunity to present his work. Well done to Vincenzo!