2021 Publications
2021
The molecular principles of gene regulation by Polycomb repressive complexes
Blackledge NP, Klose RJ.
Nat Rev Mol Cell Biol. 2021 Dec;22(12):815-833.
doi: 10.1038/s41580-021-00398-y.
Epub 2021 Aug 16. PMID: 34400841; PMCID: PMC7612013.
PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency
Dobrinić, P., Szczurek, A.T. & Klose, R.J
Nat Struct Mol Biol 28, 811–824 (2021).
https://doi.org/10.1038/s41594-021-00661-y
Getting under the skin of Polycomb-dependent gene regulation
Neil P. Blackledge and Robert J. Klose
doi:10.1101/gad.348257.121Genes & Dev. 2021. 35: 301-303
Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes
Sugishita H, Kondo T, Ito S, Nakayama M, Yakushiji-Kaminatsui N, Kawakami E, Koseki Y, Ohinata Y, Sharif J, Harachi M, Blackledge NP, Klose RJ, Koseki H. Nat Commun. 2021 Sep 9;12(1):5341.
doi: 10.1038/s41467-021-24894-z.
PMID: 34504070; PMCID: PMC8429492.
BAP1 constrains pervasive H2AK119ub1 to control the transcriptional potential of the genome
Nadezda A. Fursova, Anne H. Turberfield, Neil P. Blackledge, Emma L. Findlater, Anna Lastuvkova, Miles K. Huseyin, Paula Dobrinić, Robert J. Klose
Genes Dev. 2021 May 1;35(9-10):749-770. Epub 2021 Apr 22.
doi: 10.1101/gad.347005.120.
PMID: 33888563; PMCID: PMC8091973.
Live-cell single particle tracking of PRC1 reveals a highly dynamic system with low target site occupancy
Huseyin, M.K., Klose, R
Nat Commun 12, 887 (2021).
https://doi.org/10.1038/s41467-021-21130-6